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Medicines Company (NASDAQ?MDCO)?RNAi???????????????

来源:原创、整理时间:2018-08-27 15:01
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Medicines Company (NASDAQ?MDCO)?RNAi???????????????

2018-06-08 18:44 ??:??? ?? /?? /????

????Medicines Company (NASDAQ?MDCO)?RNAi???????????????

????????????????RNAi???????????

??????

???????????????

?????Medicines Company (NASDAQ?MDCO)

?????Alnylam Pharmaceuticals, Inc.(NASDAQ:ALNY)

Arrowhead Pharmaceuticals(NASDAQ:ARWR)

Dicerna Pharmaceuticals, Inc.(NASDAQ:DRNA)

Medicines Company (NASDAQ?MDCO)?RNAi???????????????

summary

????Alynlam(NASDAQ:ALNY)???RNAi????????????????siRNA?????Inclisiran?????PCSK9???????????Melinta(NASDAQ:MLNT)????????????????Inclisiran???????????

Inclisiran??RNA???????????PCSK9???????????????C?LDL-C??????????????????????2????????????????????????????1??2????????????????????PCSK9?????????????????????????????????????FDA?????????

????????PCSK9??????$1000??Inclisiran????????????????????????????????????????????????????????PCSK9???1?????24??Inclisiran1?????2????????????????????PCSK9???Repatha?Praluent??????Inclisiran?????????????????

?????2018?1??$150M???????????$410M?discount rate=0.2?Peak*4?????3??2-3?????30%???ALNY?roylties?15%?????????????????roylties???NPV??????$88.433/share?First Target?$88/share????????????

The Medicines Company (NASDAQ:MDCO)??????????????1996????2000?8???????????????26.5??2018?6?8????????????$55.95/share?

???????PCSK9??????

??????????????????????????????????????????????????????????????????????????????????????????????????????????

Medicines Company (NASDAQ?MDCO)?RNAi???????????????

???????????????????????????????????????????????LDL-C???<1.8mmol/L(70mg/dl)??HDL-C??<2.6mmol/L(100mg/dl)???????????????????????????first line????????????????????????Ezetimibe ??????????

????????????????????????????????????????????????????????????????????????????????????????????????????????????????????25%?????????????????????????????????????????????????????PCSK9???MDCO?????PCSK9si?????????????????????????????Inclisiran????????????

PCSK9????????????

Amgen?s (AMGN) Repatha ?Regeneron (REGN)??? and Sanofi?s (SNY) Praluent????????????Repatha??????????????????HeFH?????????????????????????????????????????????LDL-C???????Praluent???????Repatha???

?3??4??????PCSK9???????????????5?????????????????????????????????????????????????????????????

Medicines Company (NASDAQ?MDCO)?RNAi???????????????

?????????MOA Mechanism of Action?

1. RNA????

Medicines Company (NASDAQ?MDCO)?RNAi???????????????

2006??RNA???RNA interference, RNAi???????Craig Mello?Andrew Fire???????RNA???????????????????RNA?double-stranded RNA?dsRNA???????mRNA???????????Medicine?Inclisiran?2013??Alynlam(NASDAQ:ALNY)?????ALNY??Enhanced Stabilization Chemistry (ESC) GalNAc-siRNAs????RNAi?????????????????????????RNA?????????????siRNA???????????????????????20????????ALNY10??????????siRNA????????????????????????????????????????????siRNA????????????

2. PCSK9?????

???LDL-C?????LDL-C????LDLR?LDL Receptor ???????????????????????????????????LDL-C???????LDLR?LDL-C????????????????

PCSK9???????????PCSK9??????????????FH?????????????????????????????ASCVD????????LDLR???????????????????????????????PCSK9?LDLR?????????????????????PSCK9?????????LDLR???????????????LDL-C??????????????????????????????

?????????PCSK9????????????????????????? ?????????????6???????????????PCSK9???????????????????????????6%???????????????PCSK9????????????PSCK9?????????????????????

Medicines Company (NASDAQ?MDCO)?RNAi???????????????

Medicine???PCSK9si??????mRNA???????mRNA?????????PCSK9??????Repatha?Praluent?????????????PCSK9?????PCSK9???LDLR?????????????

3. IL?1??????Canakinumab

Canakinumab??????????IL?1???????IL?1????????????????????FDA?????cryopyin???????????2017?CANTOS????????????????????Canakinumab 150 mg??????????????????????????????????????????15%?????????????????Canakinumab????????????????????

4. CETP???

?????????????CETP???????????????????

????????????

1. ????Orbactiv?Minocin IV new formulation?Vabomere??2018.1.8?Melinta????????????3?????????????????????Melinta?

2. Inclisiran (PCSK9 siRAN)?????Alnylam?ESC-GaINAc-RNAi???????PCSK9???LDL-C?Indicators????????ASCVD?????????????II?ORION-1?????????????????

Inclisiran??????????

II??????????ORION-1??????580????????????Inclisran300mg?????2???6???12??????LDL-C?50.9%?38.6%?19.0%???3????????Inclisran 300mg??5???6???12??LDL-C????55.5%?52.5%?31.4%??1???60???270???6??Inclisran 300 mg???????6?????LDL-C??????50%?ORION-1???????Inclisran?????????????3??2?????Inclisran 300 mg?????????????6??????1????????????????????1???LDL-C??46%??6??????????LDL-C?51%?????????????????????????????????????????????????????2?????PCSK9mAb???????????????????????????????

Medicines Company (NASDAQ?MDCO)?RNAi???????????????

Medicines Company (NASDAQ?MDCO)?RNAi???????????????

????????????Inclisiran??????????????

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